PIPAC (Pressurized Intraperitoneal Aerosol Chemotherapy)
PIPAC is one of the newly developed promising treatment methods for ovarian, colon, stomach, pancreas and primary peritoneal tumors (mesothelioma, etc.) having spread on the abdominal membrane. PIPAC; Pressurized Intraperitoneal Aerosol Chemotherapy and HIPEC; Hyperthermic Intraperitoneal Chemotherapy are applied for pancreas cancers. In cases when systemic chemotherapy which is given from veins cannot be applied, PIPAC can be applied. The advantage is that the procedure is performed with the closed operation method (laparoscopic surgery) and side effects (pain and drug toxicity) are less. About 1/10 dose of the chemotherapic agent which is given from the vein is given to the abdomen via ports in the form of aerosol and aerosols are taken out from the 2nd port with a special absorbent system when the procedure is finished.
The application of chemotherapeutic drugs into the abdomen in the form of pressurized aerosol allows the drugs to be distributed homogenously in the abdomen, to go through more easily into the cancer cells and to keep the plasma concentration of the drugs low. Thus, it reduces the side effects of drugs. Another advantage of PIPAC is that the procedure lasts short (30 to 60 minutes) and repeatable (can be applied with intervals of 6-8 weeks).